PGD / PGS

PREIMPLANTATION GENETIC DIAGNOSIS / SCREENING (PGD / PGS)

We all want a healthy baby, one who grows into a healthy child. Unfortunately, in some cases it’s not always how things turn out. Certain genetic conditions can cause birth defects or start to show up as a child develops and certain factors, such as knowing you have a family history of a genetic disease or being of advanced maternal age, can also increase the likelihood of your baby being affected. Preimplantation Genetic Diagnosis (PGD) and Preimplantation Genetic Screening (PGS) is a way of reducing or removing that risk. Ying offers PGD/S through Genea Fertility.

PGD and PGS involves carefully removing a small number of cells from an embryo for analysis. From this tiny sample, Genea is able to test whether an embryo has Down syndrome, or any of a wide range of other previously identified familial genetic problems. These conditions typically need to be tested for separately and we will discuss with you what conditions and tests need to be considered.

Specialised PGD is most commonly used where a couple is aware of the possibility that their offspring will inherit a genetic disease. Even though they may not have a problem with infertility, the couple undergoes a stimulated IVF cycle with the aim of producing a number of embryos. Genetic material from these embryos is tested to see which, if any, of the embryos carries the genetic disease, and only embryos that do not show the disease are transferred to the woman’s uterus.

As we mentioned above, Genea’s leading approach involving biopsy at blastocyst stage results in both higher implantation rate and live birth rates when compared to the biopsy at Day 3 method still used by many other Australian clinics.

A review of information from the Australian and New Zealand Assisted Reproduction Database (ANZARD) from 2004 to 2008 showed nearly twice as many couples undertaking Day 5 biopsy on their embryo delivered a baby compared to couples whose embryo was biopsied at Day 3.

Genea uses two major types of tests or analysis:

  • Total Chromosome Analysis; and
  • Polymerase Chain Reaction (PCR);
  • Combination Polymerase Chain Reaction (Total Chromosome Analysis / PCR)

If you have or carry a diagnosed genetic problem or have suffered three or more miscarriages in a row, you can call us to discuss whether one of the above approaches is the right path for you. Genea is one of the very few centres in Australia with the vital combination of IVF and genetics facilities to perform these sophisticated tests successfully.

Please do not hesitate to contact us should you have any questions.